Kubva pakatanga denda, kuongororwa kuongororwa kwaita basa rakakosha mukudzora kupararira kweSARS-CoV-2, hutachiona hunokonzera.COVID 19.Rapid antigen bvunzoyakaitwa kumba kana mukiriniki inopa mhedzisiro mumaminetsi gumi nemashanu kana pasi.Kana munhu akakurumidza kubatwa nechirwere ichi, anobva akurumidza kutsvaga kurapwa uye kuzviparadzanisa nevamwe.Asi kana misiyano mitsva yehutachiona ikaonekwa, iwo akasiyana anogona kusaonekwa nebvunzo idzi.
Mazhinji ekukurumidza antigen bvunzo akagadzirirwa kuona iyo SARS-CoV-2 nucleocapsid protein kana N-protein.Protein iyi inowanikwa muhuwandu muhutachiona hwehutachiona uye vanhu vane hutachiona.Rapid test kits kazhinji iine masoja ekudzivirira chirwere maviri akasiyana anosungirira kunzvimbo dzakasiyana dzeN protein.Kana masoja ekudzivirira chirwere akabatana neprotein yeN mumuenzaniso, mutsara une ruvara kana chimwe chiratidzo chinobuda patest kit, zvichiratidza hutachiona.
Protein N ine 419 amino acid structural units.Chero ipi zvayo inogona kutsiviwa neimwe amino acid nekuchinja.Boka retsvakurudzo rinotungamirirwa nePh.D.Philip Frank naEric Ortlund veEmory University vakagadzirira kuongorora kuti shanduko imwe chete yeamino acid inokanganisa sei kushanda kwekukurumidza kweantigen test.Vakashandisa nzira inonzi deep mutation scanning kuti vaone panguva imwe chete kuti kuchinja kwega kwega muprotein yeN yehutachiona kunokanganisa sei kusunga kune antibody yekuongorora.Mhedzisiro yavo yakaburitswa muCell munaGunyana 15, 2022.
Vatsvagiri vakagadzira raibhurari yakazara yeinoda kusvika 8,000 N protein mutations.Izvi zvakasiyana-siyana zvinodarika 99.5% yezvese zvinogona kuchinja.Vakazoongorora kuti mutsauko wega wega waipindirana sei negumi nenomwe akasiyana ekudzivirira ekudzivirira chirwere anoshandiswa mumagetsi gumi nerimwe anowanikwa mune zvekutengesa nekukurumidza antigen bvunzo, kusanganisira zvakajairika.kumba kits.
Chikwata chakaongorora kuti ndeipi N-protein shanduko inokanganisa kuzivikanwa kweantibody.Zvichienderana neruzivo urwu, vakagadzira "kupukunyuka mutation mbiri" kune yega yega yekuongorora antibody.Iyi nhoroondo inozivisa shanduko dzakanangana muprotein yeN iyo inogona kukanganisa kugona kweantibody kusunga kune yayo chinangwa.Ongororo iyi yakaratidza kuti masoja ekudzivirira chirwere anoshandiswa mukuyedza kwemazuva ano anoona uye anosunga zvese zvakapfuura uye zvazvino zvakasiyana zveSARS-CoV-2 zvekunetseka uye kunetseka.
Kunyangwe masoja ekudzivirira chirwere akati wandei achiziva dunhu rimwechete reN protein, vaongorori vakawana kuti antibody yega yega ine siginicha yakasarudzika yekupukunyuka masinhi.Sezvo hutachiona hweSARS-CoV-2 hunoramba huchichinja uye huchigadzira zvitsva zvakasiyana, iyi data inogona kushandiswa mureza wekuedza kit masoja ekudzivirira chirwere angangoda kuongororwazve.
"Kuzivikanwa uye kwakaringana kucherechedzwa kwevanhu vane hutachiona kunoramba kuri zano rakakosha rekudzikisa COVID-19, uye kudzidza kwedu kunopa ruzivo nezve remangwana SARS-CoV-2 shanduko dzinogona kukanganisa kuonekwa," Ortlund akadaro."Mhedzisiro dzataurwa pano dzinotitendera kuti tikurumidze kujairana nehutachiona uhu sezvo misiyano mitsva iri kuramba ichibuda, ichiratidza mhedzisiro yekiriniki uye hutano hweveruzhinji."
Mhedziso: Mutation Deep Scan inoona shanduko dzekupukunyuka muSARS-CoV-2 nucleocapsid uchishandisa iripo kukurumidza antigen bvunzo.Frank F., Kin MM, Rao A., Bassit L., Liu H, Bowers HB, Patel AB, Kato ML, Sullivan JA, Greenleaf M., Piantadosi A., Lam VA, Hudson VH, Ortlund EA cell.2022 Gunyana 15;185(19):3603-3616.e13.Ministry of the Interior: 10.1016/j.cell.2022.08.010.Nyamavhuvhu 29, 2022 PMID: 36084631.
Mari: National Institute for Biomedical Imaging uye Bioengineering NIH (NIBIB), National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) uye National Institute of Allergy uye Infectious Diseases (NIAID), American Heart Association.
NIH Research Matters ndeye vhiki yekuvandudza yeakakosha NIH tsvakiridzo yakaongororwa neNIH nyanzvi.Yakaburitswa neCommunication uye Public Affairs Hofisi yeMukuru weNational Institutes of Health.